Bleeding Disorders
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There have been a small number of incidents where Greater Swiss Mountain Dogs have experienced excessive bleeding during surgical procedures, after illness/injury or spontaneous nasal bleeding without accompanying trauma.
For more information,
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Vet version: Coagulation Protein Disorder
Pet owner version: Bleeding Disorders of Dogs
https://www.merckvetmanual.com/dog-owners/blood-disorders-of-dogs/bleeding-disorders-of-dogs
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Although not common in the Greater Swiss Mountain Dog, out of an abundance of caution, owners are encouraged to make their veterinarian aware of this possible issue, so appropriate precautions can be taken during surgery or treatments.
P2Y12 Platelet Receptor Deficiency
There has been breed-specific research into a platelet receptor deficiency of the gene P2Y12 as a potential cause of some bleeding episodes. That research has been inconclusive to date.
Recent research...
Sight hound genetic study of post-operative bleeding (see article: https://phys.org/news/2023-02-genetic-deadly-disorder-dogs.html?fbclid=IwAR2P_NJb8U43V146ZPNyOYRlPJcPfj23SUXUwnjHMzsVe22Eji0owwWdQdM)
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Note from Dr. Marjory Brooks, DVM, DACVIM, Professor of Practice, Cornell University College of Veterinary Medicine (Dr. Brooks at the lead researcher on the Comparative Coagulation Section-Animal Health Diagnostic Center, Cornell University)
"The suspected disease gene identified in the paper (SERPINF2 ) codes for the protein “antiplasmin”. This protein slows the process of blood clot degradation, so that a lack of the protein results in unstable blood clots and re-bleeding after injury.
The clinical signs and ancestry (sight hounds) don’t seem to be close matches for the GSMD problem."